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Brian P. Griffin, MD, FACC

  • Director Cardiovascular Medicine Training Program
  • John and Rosemary Brown Chair in Cardiovascular Medicine
  • Department of Cardiovascular Medicine
  • Heart and Vascular Institute
  • Cleveland Clinic
  • Cleveland, Ohio

A de cit in phonological processing medications for ibs order 4mg ondansetron mastercard, accessing the individual sounds of spoken words symptoms nervous breakdown purchase ondansetron with paypal, represents the core weakness in dyslexia medicine 2355 generic 4mg ondansetron, and its remediation is the focus of early intervention programs for at-risk and struggling readers medicine used to treat bv proven ondansetron 4 mg. Dyslexia is a chronic medicine neurontin cheap ondansetron on line, persistent dif culty and is neither a developmental lag nor outgrown; the implication is that reading problems must be recognized and addressed early symptoms 9 weeks pregnancy cheap ondansetron 8mg with amex. Evidence-based interventions are now available and have positive effects on reading. The most consistent and largest effect sizes are associated with provision of prevention programs explicitly focused on phonological awareness, phonics, and meaning of text. Intervention programs for children beyond second grade, though effective, are chal lenging and have produced less-consistent results. Such evidence-based programs focus on systematic, phonologically based instruction and teaching metacognitive No single program is the most effective; many types of remediation programs can be effective. Fluency de cits have proven much more dif cult to remediate than word accuracy problems. Many children who respond to programs aimed at improving word iden ti cation skills remain dys uent, slow readers. Approaches that focus on repeated oral reading with feedback and guidance have shown the most consistent positive re sults. For readers who are not uent and cannot read individual words automatically, reading remains effortful and slow. Neurobiological studies have revealed differences in the neural circuitry for read ing between nonimpaired and dyslexic readers and identi ed a neural signature for dyslexia. Brain imaging has also indicated a target (the left occipito-temporal word form area) for intervention for skilled or uent reading and that these systems are malleable and respond to effective reading interventions. Such ndings demonstrate the importance and powerful impact of effective reading instruction. Interventions, while promising, have yet to close the gap in the ability of dyslexic children to read uently; dyslexic children often remain accurate but slow readers. Neurobiological evidence indicates that the failure of the word form area to function properly in dyslexic children and young adults is responsible for their characteristic inef cient, slow reading. Accommodations, particularly the provision of extra time, are essential for dyslexic students to fully demonstrate their knowledge. To identify which speci c instructional components/programs work best for which speci c types of dyslexic students and under what kinds of implementation practices. To identify which speci c instructional elements in which speci c combination im prove uency and reading comprehension, particularly in older students. To determine effective methods of identifying at-risk children earlier and more accu rately. To determine mechanisms by which the phonology and orthography are integrated in the word form region and how this process could be facilitated. Phonological sensitivity: a quasi-parallel progression of word structure units and cognitive operations. Instructional treatment associated with changes in brain activation in children with dyslexia. Evaluation of a program to teach phonemic awareness to young children: a 2 and 3-year follow-up, and a new preschool trial. Effects of preschool phoneme identity training after six years: outcome level distinguished from rate of response. A synthesis of research on effective interventions for building reading uency with elementary students with learning disabilities. Longitudinal models of developmental dynamics between reading and cognition from childhood to adolescence. Conceptual and Methodological Issues in Dyslexia Research: A Lesson for Developmental Disorders. New York: Guilford Fletcher J, Shaywitz S, Shankweiler D, Katz L, Liberman I, et al. Cognitive pro les of reading disability: comparisons of discrepancy and low achievement de nitions. The role of instruction in learning to read: preventing reading failure in at-risk children. The Measurement of Change: Assessing Behavior Over Time and Within a Developmental Context. Peer-assisted learning strategies: promoting word recognition, uency and reading comprehension in young children. Introduction to the Benchmark School Word Identi ca tion/Vocabulary Development Program. Phonological processing in dyslexic children: a study combining functional imaging and event related potentials. Ameliorating early reading failure by integrating the teaching of reading and phonological skills: the phonological linkage hypothesis. Dissociation of normal feature analysis and de cient processing of letter-strings in dyslexic adults. Phonological skills are (probably) one cause of success in learning to read: a comment on Castles and Coltheart. Cooperative learning for students with learning disabilities: evi dence from experiments, observations, and interviews. Cognitive factors at school entry predictive of speci c reading retardation and general reading backwardness: a research note. The Use of Fluency-Based Measures in Early Identi cation and Evaluation of Intervention Ef cacy in Schools. Transfer from word training to reading in context: gains in reading uency and comprehension. Development and Promotion of Emergent Literacy Skills in Children at Risk of Reading Dif culties. Effective Remediation of Word Identi cation and Decoding Dif culties in School-Age Children with Reading Disabilities. New York: Guilford Lovett M, Lacerenza L, Borden S, Frijters J, Steinback K, Palma M. Components of effective remediation for developmental reading disabilities: combining phonological and strategy-based instruction to improve outcomes. Critical conceptual and methodological considerations in reading intervention research. Responding to nonresponders: an exper imental eld trial of identi cation and intervention methods. Subliminal convergence of kanji and kana words: further evidence for functional parcellation of the posterior temporal cortex in visual word perception. Genetic and environmental in uences on reading and language ability and disability. Teaching Children to Read: An Evidence-Based Assessment of the Scienti c Research Literature on Reading and Its Implications for Reading Instruction: U. A positron emission tomographic study of impaired word recognition and phonological processing in dyslexic men. Early Identi cation of Children at Risk for Reading Disabilities: Phonological Awareness and Some Other Promising Predictors. Short and long-term effects of training phonological awareness in kindergarten: evidence from two German studies. A functional magnetic resonance imaging study during reading in Japanese dyslexic children. Discrepancy compared to low achieve ment de nitions of reading disability: results from the Connecticut Longitudinal Study. Development of left occipito-temporal systems for skilled reading in children after a phonologically-based intervention. Disruption of posterior brain systems for reading in children with developmental dyslexia. Overcoming Dyslexia: A New and Complete Science-Based Program for Reading Problems at Any Level. Evidence that dyslexia may represent the lower tail of a normal distribution of reading ability. Prevalence of reading disability in boys and girls: results of the Connecticut Longitudinal Study. Neural systems for compensation and persistence: young adult outcome of childhood reading disability. Some characteristics of 9-year-old boys with general reading backwardness or speci c reading retardation. Accelerating Growth and Maintaining Pro ciency: A Two-Year Intervention Study of Kindergarten and First Grade Chil dren At Risk for Reading Dif culties. Brain activation pro les in dyslexic children during nonword reading: a magnetic source imaging study. Dyslexia-speci c brain activation pro le becomes normal following successful remedial training. In Prepared for the Of ce of Education Research and Improvement Science and Technology Policy Institute. Explaining the differences between the dyslexic and the garden-variety poor reader: the phonological core variable difference model. Phenotypic performance pro le of children with reading disabil ities: a regression-based test of the phonological-core variable-difference model. Interventions for Students with Learning Disabilities: A Meta-Analysis of Treatment Outcomes. Flashcards revisited: training poor readers to read words faster improves their comprehension of text. Intensive re medial instruction for children with severe reading disabilities: immediate and long-term outcomes from two instructional approaches. Approaches to the Prevention and Remediation of Phonologically-Based Reading Disabilities. Response to treatment as a way of identifying students with learning disabilities. Response to intervention as a vehicle for distinguishing between children with and without reading disabilities: evidence for the role of kindergarten and rst-grade interventions. The nature of phonological processes and its causal role in the acquisition of reading skills. Reading acquisition, developmental dyslexia, and skilled reading across languages: a psycholinguistic grain size theory. Ordinate is Rasch scores (W scores) from the Woodcock-Johnson reading test (Woodcock & Johnson 1989) and abscissa is age in years. Both dyslexic and nonimpaired readers improve their reading scores as they get older, but the gap between the dyslexic and nonimpaired readers remains. In nonimpaired readers, three systems are evident: one anterior in the area of the inferior frontal gyrus and two posterior, the top system around the parieto-temporal region and the bottom system around the occipito-temporal region. In dyslexic readers, the anterior system is slightly overactivated compared with systems of nonimpaired readers; in contrast, the two posterior systems are underactivated. This pattern of underactivation in left posterior reading systems is referred to as the neural signature for dyslexia. Im ages on the cover and throughout this publication were taken from video footage of sessions between teachers and learners. These courses range from discrete and M any m illions of adults in England em bedded classroom and com m unity need help to im prove their literacy, provision, to voluntary and work language and num eracy skills. It is Since the launch of Skills for Life we therefore crucial that the strategy have gained an even greater insight supports and reflects the successful into the effects of low levels of literacy im plem entation of other post-16 and num eracy skills on individuals, strategies. For exam ple, adults with poor further education, and the Skills literacy and num eracy skills could Strategy, which aim s to ensure that earn up to 50, 000 less over a the skills we develop are valuable to lifetim e and are m ore likely to have young people and valued by health problem s, live in a em ployers. Our goal to im prove the disadvantaged area, or be skills of young people is also central to unem ployed. It is aim ed particularly at those who teach the Fram ework does not duplicate the literacy, language and num eracy, guidance given in the Departm ent for either within discrete provision or Education and Skills publication Access em bedded within another academ ic for All: Guidance in making the adult or vocational program m e, but who literacy and numeracy core curricula are not specialists in the field of accessible. All teachers need an awareness of the indicators of dyslexia and dyscalculia the Fram ework itself is also available and need to know how to respond in a web-based version at when they recognise them. Part of that project involved action research with organisations where approaches covered in the Fram ework are in use. On the website, together with the Fram ework, are additional m aterials from those action research projects.

Syndromes

  • Urine culture - clean catch may be done to identify the bacteria in the urine to make sure the correct antibiotic is being used for treatment.
  • Enlargement of the base of the aorta
  • Sopental
  • You can return to normal daily activities within 1-2 days. Do not have sex until your doctor says it is okay.
  • Over-the-counter or prescription pain medicine may be needed to control pain (neuralgia).
  • A large area at the base of the tongue, or a tongue that is large compared to the mouth
  • Age over 40
  • Males: 44 autosomes and 2 sex chromosomes (XY), written as 46, XY

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The bar was situated on the and served between 20-25 clients per night in a parking first floor symptoms 7 dpo bfp discount ondansetron on line. Nearly all of the respondents stated the bathroom and was forced to sleep on the floor 25 medications to know for nclex generic ondansetron 8 mg with amex. Based about their lives in general during the period in which they primarily on interviews with groups and individuals were trafficked (other than work) symptoms zinc toxicity generic 8mg ondansetron overnight delivery. Two women working with sex workers and other marginalized 63 Destination stage populations medications on airplanes purchase ondansetron visa, a number of key issues emerged: programmes) medicine organizer cheap ondansetron line. For the latter medications vertigo buy 4mg ondansetron with amex, law 40/1998 which has recently undergone significant restructuring limiting the 1. Therefore, we entered the to come into contact with women who have been network of all social institutions in the trafficked. Those providing health services to sex area: charity organisations (Catholic workers emphasised how difficult it is to even ask and non), trade unions, education and women about trafficking-related issues because they feel training agencies. Providers have demonstrated that In Italy, health services are offered based on a universal service strategies that take account of the inhibitions and approach, and, based on this perspective, the previous limitations of hidden and transient populations enable immigration law (no. In practice, this means that health care is available from two categories of providers. The Word of mouth was reported as one of the most effective first include general public services, such as public ways of reaching women according to most outreach hospitals, public clinics, family planning centres and workers. The second are dedicated recommendations from co-workers provides the initial services aimed at assisting migrant women or sex element of confidence that is not inherent in an workers. In this second case, providing health services unsolicited first visit by a previously unknown care means assisting women to access to public services (for provider. When these organisations are not promote their services by offering free condoms, health able to rely on providers who are willing to volunteer information, free clinical services, pharmaceuticals, etc. Generally, groups have found trafficking programmes (Article 18 social protection that when these individuals perceive there is some 64 the health risks and consequences of trafficking in women and adolescents. Therefore, we sent information receive a card with a code number identifying them as to all doctors of Mestre and Venice about foreigners that entitles them to specialist care, our services for irregular immigrants. Consultorio familiare, Numerous providers Mestre, Venice Providers stated that differences in language and lack of Groups trying to contact migrant women reported that in available interpreting services were a significant addition to the practical difficulties of reaching women, hindrance with clients. They explained that first-time patients, in particular, often do not seek services until Nearly all those interviewed noted that while the number pain becomes acute or the problem urgent. Some organisations type of documentation, none of the providers interviewed have, however, made great strides in accommodating a in Italy or Britain required the women to present passports more diverse population, such as those employing or other forms of identification for initial sexual health cultural mediators. Other medical practitioners might be less sensitive regarding this line of questioning. I think a cultural mediator is always London-based outreach workers consistently reported essential in working with migrants. However, there is reason to believe that the civil rights of prostitutes, Italy 65 Destination stage We use a mediator or an interpreter. Particularly in the case of trafficked women who are But still, there are problems. Mediation marginalised in multiple ways (as sex workers, migrants, is a difficult means to use. There are useful have the time or interest to provide unbiased, culturally questions to ask to establish a deeper appropriate care. Concerns about the presence of outsiders are also shared, When asked about mental health, several providers in by clients. Some women feel more embarrassed to talk about mental health professional highlighted this issue by stigmatising subjects. It is very easy, for example, word travels fast, and it is understandable for women to to transform a religious behaviour into be concerned about revealing stigmatising details to a delirium. The difference for Catholics someone who may have contact with her local ethnic [from Nigerians], for example, is that community, or her community in her home country. For most of the groups interviewed in London, access to Experienced providers have come to recognise the interpreting services is severely limited, at best. One importance of culturally competent care and creative group in London, whose client-base is approximately 80 treatment strategies: 90% migrant women has funds for only one Albanian interpreter for two outreach sessions per month. We were helping a Romanian woman Inadequate support for interpreting means that providers who was convinced she was possessed risk misdiagnosing illnesses and mis-communicating by a demon we sought help from the treatment advice. The possibility of referring her to an orthodox exorcist Several providers in Italy and Britain explained that they was not excluded. One provider explained: Providers also readily acknowledged that women Sometimes it is difficult to convince experience the normal tensions of being a foreigner that them to get treated, not because they can manifest as physical health problems. Vaccinations to prevent hepatitis B, for example, situation of these women, which is require an initial blood test and first vaccination, different from woman to woman, to avoid followed by a second vaccination one month later, and a impractical propositions. The investigation and treatment of Citta e Prostituzione, sexually transmitted infections includes an initial Italy examination with screening for infections, then follow up to ensure treatment has been successful and any Individuals working with trafficked women explain that relevant contacts traced. Nor do they have access to their medical immigration, re-traffic them, betray them to a trafficker) records or know what diagnoses and treatments they and has something to offer. The are reluctant to accept help, make follow-up frequent movement of trafficked women creates a appointments outside the outreach setting, or share particular service challenge that requires the personal information. This chapter highlights the aggregate nature of the Until trust has been established, providers strongly health risks of the destination stage. These multiple advise against asking women questions about their forms of risk and abuse reinforce and exacerbate one documentation, travel route, or other topics related to another in ways that increase morbidity and, in some legal status. It is within this reaching out for services, and for service providers to personal realm that for many women lies the danger. Frequently we meet women with In addition to the practical barriers of care provision, vaginal infections, or with discharges there are also varying, and often competing, social and related to pregnancies. The problem is cultural factors inherent in providing care to a trafficked that the [trafficking] organisation does woman. A trafficked woman is situated within and not allow the women to stay more than between cultures. Her perception of the risks she faces, three months somewhere and this her own health, and potential health care services are hampers the building of any treatment based on the social and cultural meanings derived from relation. When women are proposed a her past (home), the culture and rules of her trafficking cycle of examinations or admission to work setting, and the cultural framework of the country hospital, they do accept, but later they and community in which she is residing. This can make will not come to the service since the it difficult for providers to develop appropriate strategies organisation does not allow that. Providers assert that care is Lessons from the experiences of the women and service 67 Destination stage providers interviewed for this study suggest that health programs that incorporate mobile outreach strategies (vs. Finally, those that incorporate informed and culturally sensitive care strategies are better able to provide the information and services required by this extremely diverse and vulnerable group. References 1 See United Nations Protocol to Prevent, Suppress, and Punish Trafficking in persons, especially women and children, supplementing the United Nations Convention Against Transnational Organized Crime, Article 3 (a-d). The association of sexual abuse with pelvic pain complaints in a primary care population. Review on the influence of stress on immune mediators, neuropeptides and hormones with relevance for inflammatory bowel disease. Paper presented at the International Conference on Migration, Culture & Crime, Israel, 7 July 1999. Somatic symptoms, social support, and treatment seeking among sexual assault victims. Clinical characteristics of women with a history of childhood abuse: Unhealed wounds. Child sexual abuse, peer sexual abuse, and sexual assault in adulthood: A multi-risk model of revictimization. Interpersonal functioning among women reporting a history of childhood sexual abuse: Empirical findings and methodological issues. Illegal Labor movements: the case of trafficking in women for sexual exploitation. Sexual intercourse during menstruation and self-reported sexually transmitted disease history among women. Baltimore, Johns Hopkins School of Public Health, Population Information Program, June 1993. Interview with Metropolitan Police, Central Clubs and Vice Unit, Charing Cross, London, May 2002. Phnom Penh: International Organization for Migration and Center for Advanced Study. Commission for Filipino migrant workers health research report: An assessment of the health experiences and needs of overseas domestic workers in London and the South East of England. People for sale: the need for a multidisciplinary approach towards human trafficking. Sexual Abuse and Sexual Exploitation of children and Youth in Asia: Information Kit. Migrant Sex Workers from Eastern Europe and the Former Soviet Union: the Canadian Case. Least common are cases in which criminal evidence stage trafficked women present themselves to authorities as a victim of a crime. Generally, we try not to become involved with the welfare of people that According to the individuals interviewed in Italy, we send back. I know that sounds women wishing to leave a trafficking situation and in terrible, but need of police assistance are brought to the attention of Immigration Official, authorities via non-governmental organisations. For instance, in Italy, actions by authorities following discussion is based primarily on interviews are increasing as a result of growing anti-immigrant and with officials whose mandate included work on anti-prostitution public policies. A limited amount of additional victims of severe exploitation who are considered in information was provided by women who had been held danger as a result of trying to escape their situation]. This is the case in many countries where government the following section provides a brief overview of: policy changes on immigration are resulting in more aggressive treatment of undocumented persons, which, 1. How authorities come into contact with women; in turn, reduces the priority given to health.

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Stovall Spontaneous pregnancy loss is common treatment xanthoma purchase 8mg ondansetron amex, occurring in up to 20% of recognized conceptions medications for anxiety buy ondansetron 4 mg mastercard. Following an ectopic pregnancy medicine 48 12 buy cheap ondansetron 8 mg online, approximately 15% of women will have a subsequent ectopic pregnancy medicine cabinet with lights purchase ondansetron 4mg with mastercard. Single-dose methotrexate appears to be the treatment of choice if medical therapy is indicated and selected treatment goals for ptsd discount ondansetron 8mg amex. Surgical management and medical therapy appear to be equivalent in a randomized comparison medications errors pictures order ondansetron visa. Extrauterine or ectopic pregnancy occurs when the fertilized ovum becomes implanted in tissue other than the endometrium. Although 70% of ectopic gestations are located in the ampullary segment of the fallopian tube, such pregnancies may also occur in other sites (Fig. Abnormal intrauterine pregnancy often results in pregnancy loss early in gestation. Such losses can be related to a number of factors such as age, previous pregnancy loss, and maternal smoking (Table 20. With both abnormal intrauterine and extrauterine gestation, early recognition is key to diagnosis and management. In women who had one prior spontaneous abortion, the rate of spontaneous abortion in a subsequent pregnancy ranges from 13% to 20%; in women who had three consecutive losses, the rate is 33% (7). Patients should be reassured that, in most cases, spontaneous abortion does not recur. In women less than 36 years of age, when fetal cardiac activity is confirmed by ultrasound, the risk of spontaneous abortion is less than 4. For women older than 36, the risk of spontaneous abortion rises to 10%, and above 40 years may approach 30% (8). With pelvic ultrasound, spontaneous abortion can be differentiated into various categories, based on examination findings and ultrasound findings. Missed abortion is defined as a nonviable intrauterine pregnancy in the presence of a closed cervix and little or no abdominal cramping or vaginal bleeding and can be subdivided into anembryonic gestation and embryonic demise. Anembryonic gestation is a pregnancy where the embryo failed to develop and is confirmed when the mean gestational sac diameter measured by transvaginal ultrasound is greater than 20 mm and no embryonic pole is present. When an embryo is present with crown-rump length greater than 5 mm and no cardiac activity, this is classified as embryonic demise, and the pregnancy is nonviable (14). Threatened Abortion Threatened abortion is defined as vaginal bleeding before 20 weeks of gestation. The distinction from missed or inevitable abortion requires ultrasound documentation of an intrauterine embryo or fetus with cardiac activity. The bleeding is usually light and may be associated with mild lower abdominal or cramping pain. The differential diagnosis in these patients includes consideration of possible cervical polyps, vaginitis, cervical carcinoma, gestational trophoblastic disease, ectopic pregnancy, trauma, and foreign body. On physical examination, the abdomen usually is not tender, and the cervix is closed. Bleeding can be seen coming from the os, and usually there is no cervical motion or adnexal tenderness. In the vast majority of cases, threatened abortion does not result in a pregnancy loss, but may be associated with poor outcomes later in pregnancy. In a study of 347 patients with a first-trimester pregnancy documented by ultrasonography, the overall rate of pregnancy loss was 6. In a review of over 800 women presenting with first trimester vaginal bleeding or abdominal pain, nearly 14% with bleeding had spontaneous abortion compared with 2. Women with first trimester vaginal bleeding who do go on to have continuing pregnancies have nearly three times the risk of preterm birth between 28 and 31 weeks as women without bleeding, and a 50% higher likelihood of preterm birth between 32 to 36 weeks (19). First trimester bleeding may predict higher risk for intrauterine growth restriction, preterm premature rupture of membranes, and placental abruption (20). Bacterial vaginosis, if present, should be treated, as this is associated with increased risk for spontaneous abortion (21). Inevitable Abortion With an inevitable abortion, the volume of bleeding is often greater than with other types of abortion, and the cervical os is open and effaced, but no tissue has passed. Most patients have crampy lower abdominal pain, and some have cervical motion or adnexal tenderness. When it is certain that the pregnancy is not viable because the cervical os is dilated or excessive bleeding is present, the patient should be offered medical or surgical management. Blood type and Rh determination and a complete blood count should be obtained if there is any concern about the amount of bleeding. Incomplete Abortion An incomplete abortion is a partial expulsion of the pregnancy tissue. Lower abdominal cramping is invariably present, and the pain may be described as resembling labor. On physical examination, the cervix is dilated and effaced, and bleeding is present. If the bleeding is profuse, the patient should be examined promptly for tissue protruding from the cervical os; removal of this tissue with a ring forceps may reduce the bleeding. If the patient is febrile, broad-spectrum antibiotic therapy should be administered. Management of Spontaneous Abortion In women with stable vital signs and mild vaginal bleeding, three management options exist: expectant management, medical treatment, and suction curettage. Despite a wide range (25% to 76%) of success cited in the literature, expectant management may remain a desirable option for a stable and carefully counseled patient (23, 24). Medical management with 800 g of misoprostol placed vaginally can be up to 84% effective in achieving complete abortion (25). For incomplete abortion, the misoprostol dose can be reduced to 600 g orally or 400 g sublingually, with efficacy greater than 90% (26). Suction curettage should be performed in women with excessive bleeding, unstable vital signs, or in whom reliable follow-up is a concern. In 1992, the latest year for which statistics are published, there were an estimated 108, 800 ectopic pregnancies at a rate of 19. The observed increase may represent an increase in detection and diagnosis resulting from more sensitive ultrasound technology, and a rise in sexually transmitted illnesses and assisted reproductive technologies (27). The data on demographic trends indicate that the highest rates occurred in women aged 35 to 44 years (27. When the data are analyzed by race, the risk for ectopic pregnancy among African Americans and other minorities (20. In 1992, 9% of all maternal deaths were attributable to ectopic pregnancy, down from 15% in 1988. The risk for death is higher for African Americans and other minorities than for whites. For all races, teenagers have the highest mortality rates, but the rate for African American and other minority teenagers is almost five times that of white teenagers (28, 29). After an ectopic pregnancy, there is an 8% to 15% chance of recurrent ectopic pregnancy, with single-dose methotrexate conferring the lowest risk, while linear salpingostomy is associated with the highest risk (30). Many other risk factors, including smoking and multiple lifetime sexual partners, are weakly associated with ectopic pregnancy (32). Myoelectrical activity is responsible for propulsive activity in the fallopian tube (36). This activity facilitates movement of the sperm and ova toward each other and propels the zygote toward the uterine cavity. Estrogen increases smooth muscle activity, and progesterone decreases muscle tone. Aging results in progressive loss of myoelectrical activity along the fallopian tube, which may explain the increased incidence of tubal pregnancy in perimenopausal women (36). There is no increase in the incidence of chromosomal abnormalities in ectopic pregnancies (37). Tubal Surgery As would be expected, factors that disrupt normal tubal anatomy are the primary etiology for ectopic pregnancy. Women with prior tubal surgery have a more than 20-fold increased risk of subsequent ectopic pregnancy (32). Tubal repair or reconstruction may be performed to correct an obstruction, lyse adhesions, or evacuate an unruptured ectopic pregnancy. Although it is clear that tubal surgery is associated with an increased risk for ectopic pregnancy, it is unclear whether the increased risk results from the surgical procedure or from the underlying problem. A four to fivefold increased risk is associated with salpingostomy, neosalpingostomy, fimbroplasty, anastomosis, and lysis of complex peritubal and periovarian adhesions (38). After tubal surgery, the overall rate of ectopic pregnancy is 2% to 7%, and the viable intrauterine pregnancy rate is 50% (38). Though tubal sterilization remains one of the most effective forms of contraception, failures do occur; when they do, they are more likely to result in ectopic gestation. The 10-year cumulative incidence of pregnancy after any form of tubal sterilization is 18. Despite a greater proportion of poststerilization failures resulting in ectopic pregnancy, the absolute rate of ectopic pregnancy is decreased after sterilization (40). The 10-year cumulative incidence of tubal pregnancy after any sterilization procedure is 7. Spring clip and band application techniques have 10-year ectopic rates similar to the general incidence, 8. Women younger than 28 years at the time of sterilization are more likely to have a failure than women over 34 years. The exact risk depends on the method of sterilization, site of tubal occlusion, residual tube length, coexisting disease, and surgical technique. Prior Ectopic Pregnancy A previous history of ectopic pregnancy is a risk factor for another occurrence. The likelihood of recurrence exists because of the factors that led to an initial ectopic implantation and may be affected by the type of treatment the patient received with the first episode. There is concern that conservation of the tube at the time of removal of an ectopic pregnancy would increase the risk for recurrent ectopic pregnancy (27, 48). The rates for intrauterine pregnancy (40%) and ectopic pregnancy (15%, range 4% to 28%) are similar after tubal removal or conservation (49). In a series of 54 patients with conservative surgical procedures for management of ectopic pregnancy, the incidence of future ectopic pregnancy could be predicted by the status of the contralateral tube: normal (7%), abnormal (18%), or absent (25%) (50). In a later study of pregnancy outcomes of 200 patients treated with tubal conservation for ectopic pregnancy, preservation of the tube did not increase the incidence of repeat ectopic pregnancy, but it did improve overall fertility rates (51). The risk of recurrence after methotrexate treatment is similar to that encountered with salpingectomy (52, 53). The risk of recurrent ectopic pregnancy after two prior episodes may be as high as 30% (54). Pelvic Infection the relationship of pelvic infection, tubal obstruction, and ectopic pregnancy is well documented. Chlamydia is an important pathogen causing tubal damage and subsequent tubal pregnancy. The number of episodes of chlamydia is directly associated with risk for ectopic pregnancy. In a retrospective cohort study of 11, 000 women, those with two chlamydial infections were more than twice as likely to develop ectopic pregnancy as those with one, and women with three or more were at greater than four times higher risk (64). Women at risk for chlamydia infections should be diligently tested, treated when infection is present, and counseled about the risk of ectopic pregnancy. Contraceptive Use It is not surprising that by reducing the overall likelihood of pregnancy, contraceptive use reduces the risk of ectopic pregnancy. There is concern that because of the various mechanisms of action of contraceptives, if a pregnancy were to occur, it might be more likely to be ectopic. In a meta-analysis of 13 studies examining the relationship between contraception and the risk of ectopic pregnancy, there was no increased risk in users of oral contraceptives or barrier methods compared with pregnant controls (40). A common odds ratio could not be calculated because of heterogeneity between studies. The study with the most precise point estimate was a multinational case-control study conducted by the World Health Organization involving more than 2, 200 women, which found an odds ratio of 4. This suggests that while the intrauterine device decreases the risk of pregnancy overall, if a failure does occur, the device is more successful at preventing intrauterine pregnancy than tubal pregnancy. Other Causes Prior Abdominal Surgery Many patients with ectopic pregnancies have a history of previous abdominal surgery. In one study, there appeared to be no increased risk for cesarean delivery, ovarian surgery, or removal of an unruptured appendix (75).

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It is referred to as a learning when more complex language skills are required medicine 75 yellow cheap 8mg ondansetron mastercard, disability because dyslexia can make it very such as grammar symptoms white tongue ondansetron 8 mg with visa, understanding textbook difficult for a student to succeed academically in material medications depression purchase 4 mg ondansetron otc, and writing essays medicine 7767 buy discount ondansetron on-line. They may find it difficult to express themselves clearly medicine cabinets surface mount purchase ondansetron on line amex, or to fully the exact causes of dyslexia are still not comprehend what others mean when they speak medicine the 1975 ondansetron 4 mg low price. The effects of dyslexia reach well beyond to have problems with discriminating sounds the classroom. After experiencing a great deal of stress due to academic problems, a student may become How widespread is dyslexia Dyslexia occurs in people of all A formal evaluation is needed to discover if a backgrounds and intellectual levels. The evaluation assesses dyslexia runs in families; dyslexic parents are intellectual ability, information processing, very likely to have children who are dyslexic. Some people are identified as dyslexic early in It is used to determine whether or not a student is their lives, but for others their dyslexia goes reading at the expected level, and takes into unidentified until they get older. The testing can be in areas that do not require strong language skills, conducted by trained school or outside specialists. These Reading individuals are legally entitled to special services Learning a foreign language to help them overcome and accommodate their Correctly doing math operations learning problems. Such services include education programs designed to meet the needs of Not all students who have difficulties with these these students. Formal testing is the only way dyslexia against unfair and illegal discrimination. Most people with dyslexia need help from a teacher, tutor, or therapist specially trained in using a multisensory, structured language approach. It is important for these individuals to be taught by a method that involves several senses (hearing, seeing, touching) at the same time. Many individuals with dyslexia need one on-one help so that they can move forward at their own pace. For example, a student with dyslexia can be given extra time to complete tasks, or help with taking notes, and/or appropriate work assignments. Teachers can give taped tests or allow dyslexic students to use alternative means of assessment. Students can benefit from listening to books-on-tape and from writing on computers. Of students with specific learning disabilities who receive special education services, seventy to eighty percent have deficits in reading. If children who are dyslexic get effective phonological training in kindergarten and first grade, they will have significantly fewer problems in learning to read at grade level than do children who are not identified or helped until third grade. Seventy four percent of the children who were poor readers in the third grade remained poor readers in the ninth grade. Dyslexia affects males and females nearly equally, and people from different ethnic and socio-economic backgrounds as well. To verify that an individual is dyslexic, he/she should be tested by a qualified testing examiner. Does he have trouble with many aspects of time (telling time, remembering his birthday, days of the week, months of the year) In spelling, does he transpose silent letters within words; can he not recall correct order of letters; does he misplace silent e In math, does he sometimes work left to right, when opposite direction is called for Rule of thumb: try assigning 1/5 amount of rest of class, then slowly increasing amount. It takes many times more energy for the dyslexic student to get through the day and to do even average work, than it does the average student. The dyslexic student needs o a quiet, calm, structured, orderly, consistent and fair environment o one or two verbal instruction at a time o short, simple instructions with few words. Both general education and special education teachers seek accommodations that foster the learning and management of a class of heterogeneous learners. It is important to identify accommodations that are reasonable to ask of teachers in all classroom settings. The following accommodations appear reasonable and provide a framework for helping students with learning problems achieve in general education and special education classrooms. They are organized according to accommodations involving materials, interactive instruction, and student performance. Accommodations Involving Materials Students spend a large portion of the school day interacting with materials. Most instructional materials give teachers few activities or directions for teaching a large class of students who learn at different rates and in various ways. This section provides material accommodations that enhance the learning of diverse students. Frequently, paraprofessionals, volunteers, and students can help develop and implement various accommodations. The student can replay the tape to clarify understanding of directions or concepts. Some directions are written in paragraph form and contain many units of information. The teacher can help by underlining or highlighting the significant parts of the directions. For example: Original directions: this exercise will show how well you can locate conjunctions. When you locate a conjunction, find it in the list of conjunctions under each sentence. Directions rewritten and simplified: Read each sentence and circle all conjunctions. This technique prevents students from examining an entire workbook, text, or material and becoming discouraged by the amount of work. For example, the teacher can request the student to complete only odd-numbered problems or items with stars by them, or can provide responses to several items and ask the student to complete the rest. Finally, the teacher can divide a worksheet into sections and instruct the student to do a specific section. A worksheet is divided easily by drawing lines across it and writing go and stop within each section. If a student is easily distracted by visual stimuli on a full worksheet or page, a blank sheet of paper can be used to cover sections of the page not being worked on at the time. Also, line markers can be used to aid reading, and windows can be used to display individual math problems. If an adolescent can read a regular textbook but has difficulty finding the essential information, the teacher can mark this information with a highlight pen. In consumable materials in which students progress sequentially (such as workbooks), the student can make a diagonal cut across the lower right-hand corner of the pages as they are completed. With all the completed pages cut, the student and teacher can readily locate the next page that needs to be corrected or completed. Some materials do not provide enough practice activities for students with learning problems to acquire mastery on selected skills. Recommended practice exercises include instructional games, peer teaching activities, self-correcting materials, computer software programs, and additional worksheets. At the secondary level, the specific language of the content areas requires careful reading. A reading guide provides the student with a road map of what is written and features periodic questions to help him or her focus on relevant content. It helps the reader understand the main ideas and sort out the numerous details related to the main ideas. A reading guide can be developed paragraph-by-paragraph, page-by-page, or section-by-section. Teaching and interactions should provide successful learning experiences for each student. Some accommodations to enhance successful interactive instructional activities are: 1. Many commercial materials do not cue teachers to use explicit teaching procedures; thus, the teacher often must adapt a material to include these procedures. Students who have difficulty following directions are often helped by asking them to repeat the directions in their own words. The following suggestions can help students understand directions: (a) if directions contain several steps, break down the directions into subsets; (b) simplify directions by presenting only one portion at a time and by writing each portion on the chalkboard as well as stating it orally; and (c) when using written directions, be sure that students are able to read and understand the words as well as comprehend the meaning of sentences. Many students with learning problems need the structure of daily routines to know and do what is expected. The teacher can give a copy of lecture notes to students who have difficulty taking notes during presentations. An outline, chart, or blank web can be given to students to fill in during presentations. This helps students listen for key information and see the relationships among concepts and related information. This helps learners with limited prior knowledge who need explicit or part-to-whole instruction. Prior to a presentation, the teacher can write new vocabulary words and key points on the chalkboard or overhead. An effort should be made to balance oral presentations with visual information and participatory activities. Also, there should be a balance between large group, small group, and individual activities. Mnemonic devices can be used to help students remember key information or steps in a learning strategy. H is for Lake Huron, O is for Lake Ontario, M is for Lake Michigan, E is for Lake Erie, and S is for Lake Superior. Daily review of previous learning or lessons can help students connect new information with prior knowledge. Accommodations Involving Student Performance Students vary significantly in their ability to respond in different modes. For example, students vary in their ability to give oral presentations; participate in discussions; write letters and numbers; write paragraphs; draw objects; spell; work in noisy or cluttered settings; and read, write, or speak at a fast pace. Moreover, students vary in their ability to process information presented in visual or auditory formats. For students who have difficulty with fine motor responses (such as handwriting), the response mode can be changed to underlining, selecting from multiple choices, sorting, or marking. Students with fine motor problems can be given extra space for writing answers on worksheets or can be allowed to respond on individual chalkboards. Moreover, an outline helps students to see the organization of the material and ask timely questions. To develop a graphic organizer, the student can use the following steps: (a) list the topic on the first line, (b) collect and divide information into major headings, (c) list all information relating to major headings on index cards, (d) organize information into major areas, (e) place information under appropriate subheadings, and (f) place information into the organizer format. Students with attention problems can be seated close to the teacher, chalkboard, or work area and away from distracting sounds, materials, or objects. Students can use calendars to record assignment due dates, list school related activities, record test dates, and schedule timelines for schoolwork. Students should set aside a special section in an assignment book or calendar for recording homework assignments. Lined paper can be turned vertically to help students keep numbers in appropriate columns while computing math problems. Asterisks or bullets can denote questions or activities that count heavily in evaluation. Students can be provided with letter and number strips to help them write correctly. Number lines, counters, and calculators help students compute once they understand the mathematical operations. Samples of completed assignments can be displayed to help students realize expectations and plan accordingly. The teacher can pair peers of different ability levels to review their notes, study for a test, read aloud to each other, write stories, or conduct laboratory experiments. A student can use carbon paper or a notebook computer to take notes and then share them with absentees and students with learning problems. This helps students who have difficulty taking notes to concentrate on the presentation. Students who work slowly can be given additional time to complete written assignments. Many students with learning problems need additional practice to learn at a fluency level. For example, if a student has a writing problem, the teacher can allow her or him to outline information and give an oral presentation instead of writing a paper.

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